Abstract
Acyclic, disulphide derivatives of cysteine have been identified as moderately potent antagonists of alpha4beta1-mediated leukocyte cell adhesion to VCAM. This communication describes how they were discovered from a simple L-cystine derivative and using the structure-activity data of C*DThioPC* related cyclic peptides.
MeSH terms
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Cysteine / chemistry*
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Cysteine / pharmacology
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Integrin alpha4beta1
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Integrins / antagonists & inhibitors*
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Interleukin-8 / pharmacology
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Protein Binding
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Receptors, Lymphocyte Homing / antagonists & inhibitors*
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Structure-Activity Relationship
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Vascular Cell Adhesion Molecule-1 / metabolism
Substances
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Integrin alpha4beta1
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Integrins
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Interleukin-8
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Receptors, Lymphocyte Homing
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Vascular Cell Adhesion Molecule-1
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Cysteine